Very-long-chain n−3 fatty acids as biomarkers for intake of fish and n−3 fatty acid concentrates

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Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese

Background—Onceor twice-weekly consumption of fish (or a small amount of fish intake) reduces the risk of coronary heart disease and sudden cardiac death in Western countries. It is uncertain whether a high frequency or large amount of fish intake, as is the case in Japan, further reduces the risk. Methods and Results—To examine an association between high intake of fish and n3 polyunsaturated ...

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Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults.

Greater consumption of n3 (ω3) polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can reduce risk for cardiovascular disease events, yet their effects on metabolic risk factors and diabetes remain unclear. This cross-sectional study used a community volunteer sample to test whether the associations between n3 fatty acids and cardiometabolic risk vary as a fun...

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Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators. Our understanding on the function of VLCFAs is growing in parallel with the identi...

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Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus.

BACKGROUND Diet is a key component of a healthy lifestyle in the prevention of type 2 diabetes mellitus (T2DM). The role of long-chain omega-3 (n-3) fatty acids (LCFAs) in the development of T2DM remains unresolved. OBJECTIVE We examined the association between dietary LCFAs and incidence of T2DM in 3 prospective cohorts of women and men. DESIGN We followed 195,204 US adults (152,700 women ...

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Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers.

The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of d...

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ژورنال

عنوان ژورنال: The American Journal of Clinical Nutrition

سال: 1996

ISSN: 0002-9165,1938-3207

DOI: 10.1093/ajcn/64.3.305